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Nano electrode array particle sensor based on dielectrophoresis

Update: 2019-11-04 17:26 Source: LUFTMY

NASA has recently developed a new technology that uses nanostructured electrode arrays and unsteady electric fields to sense the presence of specific species of particles.Sample preparation is one of the key functions of biological detection.It involves controlling the particles required for separation, concentration and / or operation from the interfering substance matrix.This new technology uses the dielectric electrophoresis (DEP) effect in the non-uniform and unsteady electric field, which is produced by the spacer nanostructure array (NSS) located on the substrate surface, to control the particle separation.The object of the present invention is to promote the accumulation / concentration of selected particles (e.g. biological species such as E.coli, Salmonella and anthrax, as well as non biological materials such as nanoparticles and microparticles, quantum dots, nanowires, nanotubes and other inorganic particles) near the substrate.It also provides a sensor to detect the presence of selected species of particles in the channel liquid or fluid.

Advantage

Detection of multiple species

For organic or inorganic species

Low pressure operation

Microchip Lab

Good selectivity

No need for charged material

It can be used in high speed microfluidics

Provides a greater electric field intensity gradient

Analysis automation

Real-time monitoring

Application

Medical Science

Nanotechnology

Biomedical Science

Analysis instrument

Research and chemical laboratory

Environmental monitoring

A time-varying electrical field E, having a root-mean-square intensity of 2rms, with a non-zero gradient in a direction transverse to the liquid or fluid flow direction, is produced by a nanostructure electrode array with a very high magnitude gradient near exposed electrode tips. If the dielectric constant of the medium is basically different from that of the selected particles, the dielectric power will cause the selected particles to accumulate near the electrode tip.Insulating materials surround most nanostructured electrodes, and areas of the surface of the insulating materials are functionalized to facilitate attachment of the selected particle species to the surface. The electrical property value Z (MEAs) is measured at the functional surface and compared with the reference value Z (Ref) to determine whether the selected species particles attach to the functional surface. One advantage of this innovation is that the nanostructured electrode array can provide one or more orders of magnitude greater electric field intensity gradients than the corresponding gradients provided by the traditional microelectrode array. Because of the high intensity field gradients, the nanostructured concentrator can capture particles in the high-speed microfluidic flow. This is important for applications that must complete the entire analysis in a few minutes.

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